VAMPIRE (Variant Annotation Method Pointing to Interesting Regulatory Effects) provides a tool for the user to explore annotations encompassing 1D epigenomic signatures, variant impact on protein and gene expression, chromatin conformation information from Hi-C and similar technologies, as well as publicly available GWAS and PheWAS results, creating a comprehensive annotation profile for variants from recent trans-ethnic blood cell trait publications and preprints with a flexible interface for adding additional future GWAS results.
To visualize and leverage these multiple annotation categories for further analysis or prioritization of experimental validations, VAMPIRE effectively and efficiently displays and integrates relevant variant information, allowing the user to investigate either all the variants annotated or subsets based on annotation category groupings ('Search by Annotation Category Group' tab), searching either by variant ('Search by Variant ID' tab) or by gene name. ('Search by Gene Name' tab)
Last Updated: December 10,2020
To explore variants by their VAMPIRE annotations categories using the 'Search by Annotation Category Groupings' tab, filtering on the left side panel. Adjust for the tables displayed below by selecting from the list on the right. 'Variable level' contains selected information from their original study; '1D' refers to epigenetic annotation; '2D' refers to protein and gene expression related annotations; '3D' refers to chromatin conformation information; 'PheWAS' refers to phenotype association studies result annotations; 'GWAS' refers to genome wide association study results from the GWAS catalog.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.
Click a cell within the table for a description and interpretation details.